SnapShot: Messenger RNA Modifications

SnapShot: p53 Posttranslational Modifications

P ho sp ho ry la ti o n N-Terminal: S6, S9, S15, T18, S20 ATM, DNAPK, • CK1 ERKs, ATR, p38 • kinase, mTOR, Chk1/Chk2, JNK, MAPKAP2, Hipk4 Activated by DNA damage, UV light, ionizing radiation, replicative senes• cence, or phosphatidylcholines. N-terminal phosphorylation causes p53 stabilization by inhibiting the p53• MDM2 interaction. Knockin mice carrying separate analogs to human Ser18/ • Ser...

SnapShot: Histone Modifications

H2B H3N-PEPAKSA...PKKGSKKAVTKAQKKD...RKRSRKE SYS...YKVLK ...TGISSK...S...SEASRLAHYNKRSTITSRE...VRL ...AKH...GTKAVTKYTSAK-COO10 20 29 30 42 52 64 75 80 90 98 107 114 120 100 Ar Ph Ph Ac Ar Ph OH Ph Ph Ph Ph Me OH Me Ph Ph Ph Me Me Ph Ph Ac Me/Ac/Bu/Cr Hib/Su/Fo Ac Bu Cr Me Ac Bu Cr Hib Me Ac Bu Cr Ac Bu Cr Me/Ac/Bu Cr/Hib/Ub Me Ac Bu Cr Hib Ac Hib Me/Cr/Hib Su/ Ub / Fo Ph Og Me Ac Hib Su Fo Me/A...

Messenger RNA.

Who discovered messenger RNA?

The announcement of the discovery of messenger RNA (mRNA) and the cracking of the genetic code took place within weeks of each other in a climax of scientific excitement during the summer of 1961. Although mRNA is of decisive importance to our understanding of gene function, no Nobel Prize was awarded for its discovery. The large number of people involved, the complex nature of the results, and...

Haemoglobin messenger RNA.

This is a short review on the isolation and translation in heterologous Systems of a 9 s RNA which carries the information of haemoglobin. Rabbit haemodobin (Hb) messenger RNA (mRNA) was the first eukaryotic genetic message to be isolated, quite a long time ago (1). This was mainly due to the fact that mammalian reticulocytes offer the favourable opportunity of being highly specialized cells wh...